Publications

Our results show 1)Lamina propria macrophages are short-lived and destroyed after SIV infection. 2)Intestinal submucosa macrophages are long-lived and may become SIV/HIV reservoirs. 3)Gut biopsies are insufficient for monitoring submucosal long-lived macrophages.

Naofumi Takahashi, Chie Sugimoto, Carolina Allers, Xavier Alvarez, Woong-Ki Kim, Elizabeth S. Didier and Marcelo J. Kuroda

Blood 2009 114:2917-2925

Our results show the importance of monocyte/macrophages in the pathogenesis of AIDS and suggest the dynamic changes of the monocyte/macrophages as a new marker for AIDS progression.

Atsuhiko Hasegawa, Huining Liu, Binhua Ling, Juan T. Borda, Xavier Alvarez, Chie Sugimoto, Heather Vinet-Oliphant, Woong-Ki Kim, Kenneth C. Williams, Ruy M. Ribeiro, Andrew A. Lackner, Ronald S. Veazey and Marcelo J. Kuroda

Blood 2009 114:2917-2925

We provided a model to understand the dynamics of myeloid cells in humans during homeostasis and how age may impact these properties.

Ziyuan He, Carolina Allers, Chie Sugimoto, Nursarat Ahmed, Hideki Fujioka, Woong-Ki Kim, Elizabeth S. Didier and Marcelo J. Kuroda

J Immunol June 15, 2018, 200 (12) 4059-4067

In this review, we discuss recent data exploring the contribution of monocytes and macrophages to HIV/SIV infection and progression. Furthermore, we highlight the need to further investigate their role in pediatric cases of infection.

Kristen M. Merino, Carolina Allers, Elizabeth S. Didier and Marcelo J. Kuroda

Front. Immunol., 05 December 2017 8, 1693.

We found that increased monocyte and macrophage turnover and levels of SIV-infected lung macrophages correlated with TB reactivation. All Mtb/SIV-coinfected monkeys exhibited declines in CD4+ T cells regardless of reactivation or latency outcomes, negating lower CD4+ T-cell levels as a primary cause of Mtb reactivation.

Marcelo J. Kuroda, Chie Sugimoto, Yanhui Cai, Kristen M. Merino, Smriti Mehra, Mariluz Araínga,Chad J. Roy, Cecily C. Midkiff, Xavier Alvarez, Elizabeth S. Didier, and Deepak Kaushal

The Journal of Infectious Diseases, Volume 217, Issue 12, 25 May 2018, Pages 1865–1874.

We examined the effects of SIV infection on AMs in BAL fluid and IMs in lung tissue of rhesus macaques. SIV infection produced massive cell death of IMs that contributed to lung tissue damage. Conversely, SIV infection induced minimal cell death of AMs, and these cells maintained the lower turnover rate throughout the duration of infection. This indicates that SIV produces lung tissue damage through destruction of IMs, whereas the longer-lived AMs may serve as a virus reservoir to facilitate HIV persistence.

Yanhui Cai, Chie Sugimoto, Mariluz Arainga, Cecily C. Midkiff, David Xianhong Liu, Xavier Alvarez, Andrew A. Lackner, Woong-Ki Kim, Elizabeth S. Didier and Marcelo J. Kuroda

J Immunol November 15, 2015, 195 (10) 4884-4891.